Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

Inflamed macrophage microvesicles induce insulin resistance in human adipocytes

BACKGROUND Cytokines secreted by adipose tissue macrophages (ATMs) significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. However, little relevant information is available regarding the role of microvesicles (MVs) derived from ATMs in macrophage-adipocyte crosstalk. METHODS MVs were generated by stimulation of M1 or M2 phenotype THP-1 macro...

Macrophage Differentiation and Polarization

A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation.

BACKGROUND Macrophage activation plays a crucial role in regulating adipose tissue inflammation and is a major contributor to the pathogenesis of obesity-associated cardiovascular diseases. On various types of stimuli, macrophages respond with either classic (M1) or alternative (M2) activation. M1- and M2-mediated signaling pathways and corresponding cytokine production profiles are not complet...

Molecular Cardiology A Novel Regulator of Macrophage Activation miR-223 in Obesity-Associated Adipose Tissue Inflammation

Background—Macrophage activation plays a crucial role in regulating adipose tissue inflammation and is a major contributor to the pathogenesis of obesity-associated cardiovascular diseases. On various types of stimuli, macrophages respond with either classic (M1) or alternative (M2) activation. M1-and M2-mediated signaling pathways and corresponding cytokine production profiles are not complete...

Differentiation of C2D macrophage cells after adoptive transfer.

C2D macrophage cells protect immunocompromised mice from experimentally induced pneumonias after intraperitoneal (i.p.) adoptive transfer. These macrophage cells are immature and display minimal activity in vitro. Therefore, we wanted to understand how adoptive transfer affected these cells. We believe that the in vivo environment affects the phenotypic and functional characteristics of macroph...